The Phospho-ABL1-Y245 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Abl, ABL1, bcr/abl, c Abl, cAbl, and MTTP. This antibody recognizes Human, and Mouse antigen. The Phospho-ABL1-Y245 Polyclonal Antibody has been validated for the following applications: Immunofluorescence, and Western Blot.
Description
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11